This is surprising because risky sex (i.e., without condoms) is usually associated with negative self-esteem and depressed mood.

Among women who “always” or “usually” used condoms, about 20% reported suicidal thoughts, but among those who used condoms only “sometimes,” the figure was much lower at 7%. Among women who “never” used condoms, only 5% reported suicidal thoughts [R, R].

Semen contains many ingredients that could be responsible for this effect.

Probably the most significant one is Nerve Growth Factor (NGF), which has potent antidepressant and cognitive enhancing effects.

Semen also includes mood enhancers such as oxytocin, progesterone, endorphins, prolactin, TRH, and serotonin.

2) Semen Is Anti-Anxiety
Semen includes anti-anxiety hormones such as oxytocin and progesterone. It also has serotonin.

Few people realize that a strong driving force of anxiety comes from oxidative stress, which is why it often goes along with brain fog and fatigue issues [R].

Semen contains a lot of antioxidants to combat oxidative stress.

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3) Semen Contains Antioxidants and Combats Oxidative Stress
Semen contains a number of antioxidants such as melatonin, SOD, catalase, GPx, glutathione, Vitamin C, vitamin E, pyruvate, and carnitine [R, R].

It also includes hormones/peptides that are antioxidants, such as NGF, oxytocin, and progesterone [R, R].

Semen contains uric acid, which is also an antioxidant, but I don’t know if it’s in a meaningful concentration to be medically useful.

4) Semen Is Antiinflammatory
I’ve suffered from a lot of inflammation until I went on the lectin avoidance diet.

Semen contains anti-inflammatories/immunosuppressants so that it’s not attacked when it enters the woman.

Nerve Growth Factor, oxytocin, progesterone, testosterone, and cortisol, and certain prostaglandins are anti-inflammatories. TGF-beta in semen also helps create tolerance to proteins.

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5) Semen Contains Many Healthy Hormones
Semen has many good hormones that people are often low in:

Oxytocin – has anti-anxiety properties and helps with wound healing [R]
Progesterone – has anti-anxiety properties [R]
Pregnenolone [R]
Melatonin [R]
Follicle-stimulating hormone (FSH) [R]
Luteinizing hormone (LH) [R]
Testosterone – women can have too low or too high testosterone [R]
TRH – an anti-inflammatory and mood enhancer
Cortisol – can reduce inflammation and can be good in pulses [R]
Estrone, estrone sulphate – good if levels are too low [R]
Estrogen, Estradiol, Estriol [R]
6) Semen May Help Prevent Cancer
Studies suggest that semen might reduce breast cancer by “not less than 50%.”

This effect is attributed to various proteins, selenium, and TGF-beta in semen.

7) Semen Is a Cognitive Enhancer: It Contains Nerve Growth Factor (NGF)
Nerve growth factor (NGF) is important for the growth, maintenance, and survival of neurons, including the axons (the part where the electrical signal passes). It also promotes myelin repair, which is the coating around the axons.

Rita Levi-Montalcini won a Nobel Prize for discovering nerve growth factor and she used NGF eye drops to increase her lifespan and health.

NGF is abundant in semen. Recent studies have found that it induces ovulation (the release of the egg from ovaries) in some mammals, which can help with fertility.

Stress and anxiety decrease NGF.

Low NGF levels are found in atherosclerosis, obesity, type 2 diabetes, and metabolic syndrome [R].

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